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About the Author
Preface
Acknowledgment
Introduction
Part I Venous thrombus
Chapter 1 The origin and onset of acute venous thrombus
Chapter 2 The answer to the onset of acute venous thrombus
1.Questions from clinics
2.Protein components analysis of acute venous thrombus
3.Localization of core proteins in acute venous thrombus
4.Inevitability of building a new intravenous defense line
5.Significant downregulation of human immune system related gene mRNA expressions
6.DNA sequence mutation in familial VTE patients
7.Immune cell function with VTE
8.Malignancy and VTE
9.Expression of same / different proteins in venous thromboembolism and different risk factor group patients
10.Core proteins may serve as new specific protein markers for VTE diagnosis
References
Chapter 3 Components of acute venous red thrombus
1.Pathology of acute venous thrombus
2.Main protein components of acute venous thrombus
3.Core proteins in acute venous thrombus
4.The inflammatory immune adherence is involved in the whole process of acute venous thrombosis
5.Nest-like biological venous filter within acute venous red thrombus
6.Venous Thrombosis is a product in proliferation of cancer cells
Chapter 4 Cytological detection of core proteins
1.A New marker for diagnosis of VTE
2.Increased expressions of integrin subunits β1, β2 and β3 in patients with acute infection
3.Increased expressions of integrin subunits β1, β2 and β3 in patients with cancer
4.Expression of the same or different proteins in venous thromboembolism and different risk factor group patients
Chapter 5 Venous thrombus and pathogenic microorganism
1.Severe Acute Respiratory Syndrome and VTE in multiple organs
2.Virus-like structure in a patient with pulmonary hypertension and VTE
3.Bacteremia and the occurrence of VTE in multiple organs
Chapter 6 Function and regulation of the immune system
1.Immune function
2.Factors affecting immune cell functions
References
Chapter 7 General theory of genomics in patients with symptomatic pulmonary thromboembolism (PE)
1.Pandect—Network analysis of human genome differences
2.Systematics of genomics
Chapter 8 Characterization of immune cell perforin mutations in a family with VTE
Clinical data of this Chinese family
Exon capture and next-generation sequencing
Sequence mapping and single nucleotide variation identification
Examining PRF1, HTR2A and ABCC8 mutations in control individuals
Examination of differentiation antigens on immune cells
Detection of complement components
Exome Sequencing
Mutations of 2 genes predicted to be functionally damaged
References
Chapter 9 VTE and immune cell dysfunction
1.The patients with acute PE and Dysfunction of CD3CD8 T cells
2.T cell-mediated immune deficiency in patients with CTEPH
3.Symptomatic VTE is a disease related to infection and immune dysfunction
4.Acute VTE and high expression of CH50
Part II Arterial thrombus
Chapter 10 New viewpoints on the pathogenesis of acute arterial thrombosis
References
Chapter 11 Human genomics in patients with acute myocardial infarction—pandect
Acute arterial thrombosis and differentially expressed genes—Significantly reduced function of T cells
Patient information
Gene expression chips
Total RNA isolation
RNA amplification and labeling
Microarray hybridization
Chip scan and Data acquisition
RT-PCR
Data analysis
Results
References
Chapter 12 Human genomics in patients with acute myocardial infarction
1.Expression characteristics of neutrophil and mononuclearphagocyte related genes in patients with AMI and SAP
2.Expression characteristics of natural killer cell related genes mRNA in patients with AMI and SAP
3.Expression characteristics of complement system related genes in patients with AMI and SAP
4.Expression characteristics of cytokine related genes in patients with AMI and SAP
5.Expression characteristics of T cell related genes in AMI and SAP patients
6.Expression characteristics of B cell related genes in patients with AMI and SAP
7.Comparison of gene expression of Integrin β2 between AMI and SAP patients
Chapter 13 The impaired innate and adaptive immunity in patients with coronary artery diseases
Part III Summary and prospect
Chapter 14 Differences of origin and onset between acute venous and arterial thrombus
1.Gist of acute venous thrombosis
2.Gist of acute arterial thrombosis
3.Similarities and differences of internal and external factors between acute venous and arterial thrombosis
Chapter 15 Epilogue: To make it simple

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版权

The Origin and Onset of Thrombus Disease: collapsed balancing function of immune cells and triggering factors 血栓病的起源与发生:免疫细胞平衡功能崩溃与启动机制